Amy Schumer Weight Loss: Her Complete Journey in 2025

21 November 2025 weightlasting.com Weight Loss

Amy Schumer Weight Loss :Amy Schumer has been making headlines lately, and it’s not just for her comedy. The 44-year-old actress and comedian has undergone a noticeable weight loss transformation that has fans talking. From deleting her Instagram photos to opening up about weight loss medications, Amy’s journey has been anything but private. Let’s dive into everything you need to know about Amy Schumer’s weight loss story, told in a straightforward and honest way.

Did Amy Schumer Delete Her Instagram Photos?

Yes, she did. In November 2025, Amy Schumer surprised her followers by deleting nearly all of her old Instagram posts. She left just one new photo on her feed, showing herself in a red strapless minidress paired with black Chanel heels.

When she announced the decision, Amy wrote: “I actually left my house tonight. Who’s proud? I’m feeling good and happy. Deleted my old pics for no reason!” She also shared her very first Instagram post to her Stories before clearing her account, saying: “My first ever insta post. I’m gonna erase them all cause why not?”

Why Did She Delete Her Photos?

At first, many people assumed Amy deleted her old photos because she wanted to hide her pre-weight loss pictures. Tabloids and social media users speculated that she was ashamed of how she looked before losing weight. But Amy quickly shut down that narrative.

She addressed the speculation directly, clarifying that she didn’t delete her old photos because they showed her before weight loss, calling this explanation a narrative created by the media. In a lengthy Instagram post, she explained:

“Hey media outlets. I didn’t delete my old photos because they were pre me losing weight. That’s a narrative you created. I’m proud of how I’ve looked always. I have been working to be pain free and I finally am. My endometriosis is better. My back is healing. I no longer have Cushing syndrome so my face went back to normal.”

She continued: “I am grateful to be strong and healthy especially for my son. But your Instagram is not your identity.”

This response shows that Amy’s focus has always been on health, not just appearance.

Amy Schumer’s Weight Loss Journey: The Full Story

Amy Schumer’s weight loss didn’t happen overnight. It’s been a journey involving multiple medications, health challenges, and a lot of honesty with her fans.

The Ozempic Experience: 2022

About three years ago, Amy tried Ozempic, a type 2 diabetes medication that has become popular for weight loss, and she lost 30 pounds quickly. She opened up about this experience on The Howard Stern Show in early 2025 while promoting her movie Kinda Pregnant.

The weight loss was dramatic and fast. Amy said, “I lost 30 pounds so quick. I looked great, but I couldn’t lift my head off the pillow. So what’s the point?”

The problem was the side effects. Amy experienced severe nausea that left her bedridden. She couldn’t even play with her young son, Gene. “I was like bedridden. I was like, vomiting—and then you have no energy. But other people take it and they’re all good. So, God bless them,” she recalled.

Why Ozempic Didn’t Work for Amy

Amy explained that her reaction to Ozempic wasn’t entirely the medication’s fault. She has a specific gene called GDF-15, which makes her extremely prone to nausea. This is the same reason she was so sick during her pregnancy with her son.

“I have this gene, GDF-15, which makes you extremely prone to nausea, which is why I was so sick during my pregnancy,” she said. Because the side effects were so severe and affected her ability to care for her son, Amy decided the medication “wasn’t livable” for her.

She stopped taking Ozempic, even though it had helped her lose weight, because being healthy meant more than just looking good.

Trying Wegovy: Another Setback

Amy didn’t give up on weight loss medications entirely. She also tried Wegovy, another GLP-1 medication similar to Ozempic. Unfortunately, she had the same problem.

“Three years ago, I tried Wegovy. I was puking, I couldn’t handle it. I don’t know if they’ve changed the formula, whatever,” she shared in a video on Instagram in March 2025.

Like Ozempic, Wegovy made her too sick to function normally, so she had to stop taking it.

Success with Mounjaro: 2025

After two failed attempts with weight loss medications, Amy finally found success with Mounjaro in 2025. In March 2025, she revealed on Instagram that she was having a positive experience with Mounjaro, unlike her previous attempts with other weight loss medications.

Amy discovered Mounjaro through a telehealth meeting with Midi Health, a women’s health company. “I went on this Telehealth meeting with Midi Health, and it was cheap. I wanted to try it myself ’cause I wanted to recommend it to my friends who are nurses and teachers,” she explained.

The Perimenopause Discovery

Here’s where Amy’s story gets really interesting. When she met with the doctors at Midi Health, they didn’t just talk about weight loss. They put her on estrogen and progesterone after discovering she was in perimenopause.

“I realised I was in perimenopause and my symptoms from being perimenopausal have disappeared,” Amy said.

This discovery changed everything for her. The hormone treatment, combined with Mounjaro, led to improvements that went far beyond just weight loss:

Her hair became fuller
Her skin improved
She had more energy
Her endometriosis symptoms got better
She even noticed an improvement in her sex drive (“I want to get down more, if you know what I mean. I’m talking about sex. So that’s been great and Mounjaro’s been great,” she joked)

Being Honest About the Cost

Amy has always been upfront about her experiences, and she didn’t hide the fact that Mounjaro isn’t covered by insurance for everyone. She explained:

“Look, it’s not covered by insurance unless you have diabetes or like severe obesity, which most of the internet thinks I have. But I’m having a really good experience with it and I wanted to keep it real with you about that.”

This honesty is refreshing in a world where many celebrities hide how they really lose weight.

Amy’s Other Health Challenges

Amy’s weight loss journey is connected to several other health issues she’s been dealing with. Understanding these gives us a fuller picture of why she’s been so focused on her health.

Cushing Syndrome

Amy has been open about experiencing Cushing syndrome, a condition where the body produces too much cortisol, which in her case caused a rounded face and weight gain. This condition affected her appearance and made weight management even more challenging.

In her Instagram post, Amy mentioned that she no longer has Cushing syndrome, so her face has returned to normal. This was a significant health improvement for her.

Endometriosis

Amy has struggled with endometriosis, a painful condition affecting the reproductive system. In her recent Instagram statement, she said her endometriosis is better now, which has contributed to her overall feeling of wellness.

Back and Hip Pain

In 2018, Amy revealed she was dealing with severe back and hip pain from old volleyball and surfing injuries, including a herniated disc, a bulging disc, and a labral tear in her hip. She worked with trainers to build strength and improve her condition.

In her November 2025 post, Amy said her back is healing, showing that her focus on health has paid off in multiple ways.

Liposuction in 2022

Amy has been honest about cosmetic procedures too. In 2022, after undergoing a hysterectomy, appendix removal, and cesarean section, Amy decided to get liposuction to feel better about her body.

She didn’t hide this fact. In fact, she called out other celebrities for not being honest about their procedures: “Everyone has been lying saying, ‘Oh smaller portions.’ Like shut the f*ck up. You are on Ozempic or one of those things or you got work done. Just stop. Be real with the people. When I got lipo, I said I got lipo.”

This transparency is one of the things fans appreciate most about Amy.

Amy Schumer’s Weight Loss Transformation: The Results

By October 2025, Amy showcased her dramatic weight loss transformation when she stepped out in a Miu Miu minidress with slim legs at a Paul McCartney concert in Las Vegas.

Photos from the event showed a noticeably slimmer Amy posing with friends Jillian Bell and Alex Saks. She wore a black short-sleeved minidress with gold buttons and matching open-toe heels.

Celebrities and fans flooded her Instagram comments with compliments:

Amy Sedaris commented: “You look incredible. Look at those pins!!! #miumiu Classy!!”
Chelsea Handler wrote: “Yes!!!!! Look at this pic!!!!”
Kathy Griffin joked: “I’m so pissed about your legs, I can barely talk to you”
Lee Daniels wrote: “Skinnnnnnnny mommmmma”

Amy responded to the love, writing: “Loving the love. My legs thank you!”

The Divorce Rumors: Setting the Record Straight

When Amy deleted her Instagram photos and showed off her weight loss, tabloids immediately started speculating about her marriage. The Daily Mail reported that Amy and her husband, chef Chris Fischer, were “100 percent” getting divorced.

The outlet pointed out that Amy hadn’t been seen with her husband for several months and had been spotted without her wedding ring. Combined with the Instagram purge and her transformation, people assumed she was leaving her marriage now that she’d lost weight.

Some social media comments were harsh: “Now that she’s skinny, she thinks she can do better,” one person wrote. Another said, “When your woman starts working out, losing weight, buying new clothes, you best get mentally ready to get dumped.”

The Truth About Her Marriage

But according to a source who spoke to People magazine, Amy and Chris Fischer are not divorcing but remain committed to their relationship and are working through normal issues that affect couples in long-term marriages. The source said, “They are both committed to the relationship.”

Amy and Chris have been married since 2018, which means they’ve been together for seven years. They share a 6-year-old son, Gene.

While it’s true that relationships go through ups and downs, especially after major life changes like weight loss, there’s no solid evidence that Amy is ending her marriage.

Amy’s Focus: Health, Not Just Weight

Throughout her entire journey, Amy has emphasized that her goal was never just to be thinner. It was to be healthy and pain-free.

In her Instagram statement responding to the speculation about deleting photos, she made this crystal clear: “I have been working to be pain free and I finally am.”

She also noted that her weight will likely continue to fluctuate: “But your Instagram is not your identity. I expect to always fluctuate and I’m 44.” This realistic approach shows maturity and self-acceptance.

Amy said her focus was on being healthy and pain-free rather than weight loss, noting improvements in her endometriosis, back healing, and resolution of Cushing’s syndrome.

Amy’s Message About Being Honest

One thing that stands out about Amy Schumer’s weight loss journey is her commitment to honesty. In Hollywood, where many celebrities pretend they lost weight through “eating clean” or “portion control,” Amy has been refreshingly transparent.

She’s talked openly about:

Using Ozempic (and why it didn’t work)
Trying Wegovy (same story)
Finding success with Mounjaro
Getting liposuction
Using hormone therapy for perimenopause

On Watch What Happens Live in June 2023, Amy called out the dishonesty in Hollywood: “Everyone has been lying saying, ‘Smaller portions.’ Shut the f–k up. You are on Ozempic or one of those things, or you got work done. Just stop. Be real with the people.”

This honesty helps other women feel less alone in their struggles. It also helps set realistic expectations about weight loss and health.

Amy’s Life Beyond Weight Loss

While weight loss has been a big part of Amy’s recent story, she’s been busy with other parts of her life too.

Her Career

Amy recently appeared in the movie Kinda Pregnant, which came out in 2025. She’s continued her comedy work and remains a prominent voice in entertainment.

Motherhood

Amy frequently mentions her son, Gene, in her discussions about health. Her inability to play with him while on Ozempic was a major reason she stopped taking it. Being a present, active mom is clearly one of her top priorities.

Advocacy

By being open about her experiences with weight loss medications, perimenopause, endometriosis, and other health issues, Amy has become an advocate for women’s health. She’s showing women that it’s okay to use medical help to feel better and that health is about more than just a number on a scale.

What About Weight Loss Medications?

Amy’s story raises important questions about weight loss drugs like Ozempic, Wegovy, and Mounjaro. These medications, known as GLP-1 agonists, work by suppressing appetite and helping regulate blood sugar.

Who Should Use Them?

These medications are officially approved for people with type 2 diabetes and, in some cases, people with obesity. As Amy pointed out, they’re not typically covered by insurance unless you have diabetes or severe obesity.

The Side Effects

Amy’s experience shows that these medications don’t work for everyone. Common side effects include:

Nausea
Vomiting
Fatigue
Digestive issues

For some people, like Amy with her GDF-15 gene, the side effects can be severe enough to make the medication unusable.

The Importance of Medical Supervision

Amy found her success with Mounjaro through a telehealth service that provided proper medical supervision. She didn’t just order the medication online and start using it. She worked with doctors who also identified her perimenopause and prescribed hormone therapy.

This comprehensive approach to health—not just focusing on weight—is what made the difference for Amy.

Lessons from Amy Schumer’s Weight Loss Journey

What can we learn from Amy’s experience?

1. Health Is More Than Just Weight

Amy’s journey shows that true wellness includes managing pain, treating underlying conditions like endometriosis and Cushing syndrome, addressing hormonal imbalances, and having energy to live your life fully.

2. What Works for One Person May Not Work for Another

Amy tried three different medications before finding one that worked for her. Even popular options like Ozempic aren’t right for everyone.

3. Honesty Matters

By being transparent about her struggles and successes, Amy has helped destigmatize the use of medical interventions for weight loss and health.

4. You Don’t Have to Hide Your Past

Amy made it clear that she’s not ashamed of how she looked before losing weight. She deleted her Instagram photos for her own reasons, not because she was embarrassed.

5. Professional Help Is Important

Working with doctors, trainers, and nutritionists gave Amy the support she needed to succeed safely.

The Bottom Line: Amy Schumer’s Weight Loss in 2025

Amy Schumer’s weight loss journey has been anything but simple. After struggling with severe side effects from Ozempic and Wegovy, she found success with Mounjaro in 2025. But her transformation is about much more than just losing weight.

Amy’s story includes:

Managing multiple health conditions
Discovering she was in perimenopause
Getting treatment for hormonal imbalances
Finally becoming pain-free
Being honest with fans about her journey

When she deleted her Instagram photos in November 2025, it wasn’t about hiding her past. It was about making a fresh start and focusing on how she feels now: healthy, happy, and pain-free.

At 44 years old, Amy is showing women that it’s never too late to prioritize your health. Whether you’re dealing with perimenopause, chronic pain, weight concerns, or other health issues, her message is clear: use the tools available to you, work with medical professionals, and don’t let anyone shame you for taking care of yourself.

Amy Schumer’s weight loss transformation is impressive, but her transformation into someone who’s pain-free, energetic, and thriving is even more inspiring. And by being honest about every step of the journey—the failures, the successes, and everything in between—she’s helping other women feel less alone in their own health struggles.

That’s the real story behind Amy Schumer’s weight loss: it’s not just about looking different. It’s about feeling better, living fully, and being honest about what it really takes to get there.